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Its active ingredient, orforglipron, is a non-peptide small molecule synthesized from scratch to mimic GLP-1 receptor activation without being a peptide chain at all

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But the biological plausibility is strong enough that ongoing randomised controlled trials are now testing GLP-1 agonists explicitly for substance use disorders, including nicotine dependence

His family history worried him, too, as diabetes and obesity run on his moms side and heart conditions on his fathers

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